Total flavonoids of Scutellariae Barbatae D. Don have been reported to inhibit invasion of hepatocellular carcinoma via matrix metalloproteinases (MMP)/metalloproteinases (TIMP) and inhibit human breast carcinoma bone metastasis by inhibiting the parathyroid hormone-related protein (PTHrP) pathway [25, 26]. This evidence concerns the gene TIMP1 and hepatocellular carcinoma.