Type 2 diabetes mellitus (T2DM) is an important endocrine and metabolic disorder, which is caused by the impairment of insulin's ability to reduce blood glucose level due to the deficiency of insulin release and action, leading to hyperglycemia [3, 4], which is also the main clinical feature of T2DM [5, 6]. The gene discussed is INS; the disease is type 2 diabetes mellitus.