IGHE and Alzheimer disease: Interestingly, previous studies have reported that the whole extracts of Lonicerae Flos or Scutellariae Radix did not influence the serum IgE in murine models of AD [12, 15] but that a mixture of their main compounds (hederagenin and baicalein) significantly inhibited serum IgE increases in DNCB-induced mice.