Finally, a case study was introduced, enhancer: chr1:1186391–1186507 ∼ miR-200a was highly relevant to the survival of thyroid cancer patients and the cis- expression quantitative trait loci (eQTL) SNP on the enhancer affected the expression of the TNFRSF18 gene as a tumor suppressor. This evidence concerns the gene TNFRSF18 and thyroid cancer.