The results showed that six lncRNAs (AC069120.1, AC103740.1, AL109615.3, H19, ST8SIA6-AS1, and TSPEAR-AS2), three mRNAs (FOXG1, HIF3A, and SPTBN2), and five miRNAs (hsa-mir-126, hsa-mir-186, hsa-mir-301a, hsa-mir-526b, and hsa-mir-3942) were identified as cancer-promoting factors because of their high expression correlation with shorter OS in patients with CRC. The gene discussed is SPTBN2; the disease is cancer.