Using a stepwise multivariate Cox proportional hazards regression analysis, we indicated that nine-lncRNA (AC103740.1, AC069120.1, CASC11, AC016027.1, ST8SIA6-AS1, AL109615.3, H19, MIR17HG, and TSPEAR-AS2) signatures, eight-miRNA (hsa-mir-20a, hsa-mir-376b, hsa-mir-526b, hsa-mir-126, hsa-mir-301a, hsa-mir-186, hsa-mir-3942, and hsa-mir-144) signatures, and five-mRNA (HIF3A, SPTBN2, DACH1, EREG, and FOXG1) signatures showed a significant prognostic value for CRC. This evidence concerns the gene SPTBN2 and colorectal carcinoma.