If we assume the antisense – sense relationship between GABPB1-AS1 and GABPB1 to be an antagonistic one, it would suggest that GABPB1-AS1 downregulates GABPB1, which in turn would lead to repression of BRCA1. This would be consistent with the results of this study: SNPs associated with reduced GABPB1-AS1 are also associated with reduced breast cancer risk, and this effect could be the result of the increased GABPB1 expression leading to increased BRCA1 expression. The gene discussed is BRCA1; the disease is breast carcinoma.