Twelve factors that satisfied the following were identified: [1] methylation variable positions in sepsis patients and control (p < 0.05); [2] differentially expressed genes in survival sepsis patients, dead sepsis patients and control (FDR ≤ 0.05 AND |log2Ratio|≥1); [3] core factors in the NF-κB pathway; and [4] included in the Raybio® C-Series Custom Cytokine Antibody Arrays list (Supplementary Figure 3A). This evidence concerns the gene NFKB1 and Sepsis.