An open-label, multicenter, non-randomized phase I and phase II clinical trial using a humanized mAb against TIM-3 (BGB-A425) combined with humanized mAb against PD-1 (tislelizumab) is recruiting to test the safety and anti-tumor effect in patients with advanced solid tumors (NCT03744468). The gene discussed is PDCD1; the disease is neoplasm.