To date, multiple clinical trials are evaluating several anti-LAG-3 mAbs for both solid and hematological cancers, both alone and in combination with anti-PD-1 mAbs (NCT01968109, NCT02061761, NCT02658981, NCT02966548, NCT03005782, NCT03250832, NCT03311412, NCT03365791, NCT03459222, NCT03489369, NCT03623854, NCT03743766, and NCT04080804). Here, PDCD1 is linked to hematopoietic and lymphoid cell neoplasm.