CLOCK and epilepsy: Figure 2 [adapted from (59)], provides a more comprehensive summary of core circadian clock genes and also draws connections between critical clock feedback loops and epilepsy. Overall, two main feedback loops lead to the cyclical fluctuation of levels of “clock proteins” that go on to activate/inactivate other biomolecular processes/substrates (e.g., “clock-controlled genes”) in a time-dependent manner, i.e., circadian regulation (60).