We first compared the levels of 13 stable plasma biomarkers involved in immune and neuroendocrine regulation (YKL40, CatS, sTNFR1, BDNF, sgp130, IL-1RA, Alcam, MPO, CXCL16, Park7, vWF, OPG, and PTX3) in the Cannabis user versus non-user groups among BD and SCZ patients. This evidence concerns the gene TNFRSF11B and Behcet disease.