Inflammation in the IVD can be characterized by an increased expression of pro-inflammatory molecules such as interleukin (IL)-6, IL-1β, and tumor necrosis factor alpha (TNF-α), and contributes to the development of degenerative disc disease (DDD) and low back pain (LBP) (Molinos et al., 2015). This evidence concerns the gene TNF and intervertebral disk degenerative disorder.