Although there is no direct evidence that SSP treats IBD by regulating immune memory, we found that SSP relieved experimental colitis by inhibiting the PI3K/Akt signaling pathway and regulating the balance between proinflammatory and anti-inflammatory cytokines (Liu et al., 2012; Zhao et al., 2013; Liu et al., 2015). Here, AKT1 is linked to inflammatory bowel disease.