Repulsive guidance molecule A (RGMa), a GPI-linked glycoprotein, inhibits axon growth by interacting with its neuronal receptor neogenin, but it also promotes reactive astrogliosis and glial scar formation by activating the TGFβ1-Smad2/3 signaling pathway and preventing neurological functional recovery after stroke (Zhang et al., 2018). Here, RGMA is linked to Stroke.