In fact, several studies have described a number of natural pharmacological modulators that can co-activate antioxidant defense and neurotrophin signaling-mediated cell survival systems (Gao et al., 2015; Kwon et al., 2015; Zhang et al., 2017; Cui et al., 2018; Fang et al., 2018; Hui et al., 2018), and suggested that these compounds have therapeutic potential for the treatment of OS-mediated brain disorders. This evidence concerns the gene BDNF and brain disorder.