6′-O-Galloylpaeoniflorin, a galloylated derivative of paeoniflorin isolated from peony root, protected an OGD-induced ischemic PC12 cell model and a CIRI male Wistar rat model against ischemic stroke by activating PI3K/Akt/Nrf2 (Wen et al., 2018). This evidence concerns the gene AKT1 and ischemic stroke.