On the contrary, phytochemicals (for example, resveratrol, tea polyphenols, and some other compounds mentioned earlier) that were shown to promote the regeneration capacity of neurons along with their protection by dual targeting TrkB/PI3K and Nrf2-ARE signaling (Qi et al., 2017; Hui et al., 2018) may have a better chance of succeeding in the clinical trial with AD subjects. The gene discussed is NFE2L2; the disease is Alzheimer disease.