In the current study, prenatal poly(I:C) exposure dramatically altered the spatial distribution and transcript level of oligodendroglial molecular signatures including SOX10, MAG, and Tf in memory and social interaction-related brain regions including mPFC, hippocampus, amygdala, neocortex, and thalamus, which lends support to the notion that white matter abnormalities have their anatomical substrates at the molecular level in neurodevelopmental disorders such as ASD and schizophrenia. This evidence concerns the gene SOX10 and neurodevelopmental disorder.