Moreover, mutations of Rabs or Rab-related proteins are known for developmental and degenerative disorders; those are Rab7 in Charcot-Marie-Tooth disease type 2B (CMT2B); Rab3GAP in Warburg Micro Syndrome, Rab27A in Griscelli syndrome type 2, Rab39B in X-linked mental retardation, and LARK2 in Parkinson’s disease (Kiral et al., 2018; Shikanai et al., 2018; Kuwahara and Iwatsubo, 2020). Here, RAB27A is linked to Autosomal dominant Charcot-Marie-Tooth disease type 2B.