APP and Alzheimer disease: In AD, Rab11 regulates the production of amyloid β through the endosomal trafficking of amyloid precursor protein (APP) and its cleavage enzymes, BACE1 and the presenilin complex (Udayar et al., 2013; Buggia-Prévot et al., 2014; Furusawa et al., 2019; Arbo et al., 2020).