For example, studies have shown that lncRNA-MEG3 overexpression can inhibit the PI3K/Akt pathway, increase the Bax, p53 and cleavage caspase-3 expression, and enhance neuronal injury induced by subarachnoid hemorrhage (SAH) (Liang et al., 2018). This evidence concerns the gene MEG3 and subarachnoid hemorrhage.