For example, studies have shown that lncRNA-MEG3 overexpression can inhibit the PI3K/Akt pathway, increase the Bax, p53 and cleavage caspase-3 expression, and enhance neuronal injury induced by subarachnoid hemorrhage (SAH) (Liang et al., 2018). Here, CASP3 is linked to subarachnoid hemorrhage.