Neurons express P2X7 receptors (Yu et al., 2008; Díaz-Hernández et al., 2009; Miras-Portugal et al., 2017; but see also Illes et al., 2017), and its blockade prevents ATP excitotoxicity and reduces the damage in models of both in vivo and in vitro ischemia (Arbeloa et al., 2012; Cisneros-Mejorado et al., 2015a). The gene discussed is P2RX7; the disease is ischemia.