Zhang et al. found that activating GABAA receptors with baicalein significantly reduced Aβ production by increasing sAPPα in wild-type APP-overexpressing CHO cells and also had an effect in 6-month-old Tg2576 AD mice treated for 8 weeks, decreasing AD-like pathology and improving cognitive performance (Zhang et al., 2013). This evidence concerns the gene APP and Alzheimer disease.