APP and Alzheimer disease: These neural circuits are overactive in different transgenic AD mouse models including hAPP-J20, Tg2576, 5xFAD, 3xTg-AD, and APP/PS1 mice (Verret et al., 2012; Flanigan et al., 2014; Palop and Mucke, 2016; Shu et al., 2016; Cattaud et al., 2018; Lerdkrai et al., 2018; Table 2).