The role of the Nrf2 in ischemic stroke and its underlying neuroprotection has also been evidenced using different ischemic stroke rodent models (Wang X. J. et al., 2007; Aguilera et al., 2018; Solleiro-Villavicencio and Rivas-Arancibia, 2018; Kishimoto et al., 2019). Here, NFE2L2 is linked to ischemic stroke.