Previous studies reveal that the Nrf2 network plays a central role in the cellular adaption by dealing with a wide range of cytoprotective proteins, counteracting distinct endogenous and exogenous insults, and providing a promising optimal therapeutic target against multiple diseases from cancer to vascular and brain disorders (Dinkova-Kostova et al., 2018; Sivandzade et al., 2019; Panieri and Saso, 2019; Brandes and Gray, 2020). This evidence concerns the gene NFE2L2 and brain disorder.