Although the number of cell lines used was limited, GBM cells with highly activated PI3K-AKT signaling tended to be more resistant to TH588 (IC50 values for the p-AKT low, medium and high groups were > 14.56, 9.19 and 8.98 μM, respectively, Fig. 6g). The gene discussed is PIK3CA; the disease is glioblastoma.