Studies have found that HBx could regulate hepatocytes proliferation, regeneration and apoptosis through several signaling pathways, such as PI3K/Akt-mTOR signaling pathway 12, STAT3/Nanog signaling pathway 13 and Wnt/β-catenin signaling pathway 14 to promote the progression of HCC and other liver diseases. Here, AKT1 is linked to hepatocellular carcinoma.