With western blot and immunofluorescence (Figure 4B–4E and Figure 5), we found that the protein levels of occludin, claudin-1, and ZO-1 were reduced in DSS-induced colitis colonic tissues, and the reduction in miR-155 levels by miR-155 antagomir treatment increased the expression of these proteins (P<0.01). The gene discussed is TJP1; the disease is colitis.