DICER1 and thyroid cancer, nonmedullary, 2: Interestingly, out of the other four published MV-FTC cases, two of these carried double DICER1 mutations: an exon 16 splice site mutation plus a codon 1705 hotspot mutation in one case, as well as an exon 24 frameshift alteration and a codon 1810 hotspot mutation in the second case [28].