With regard to NGFR, the present study provides evidence that one mechanism by which VPA upregulates p75NTR expression involves the depletion of the PRC2 core component EZH2 and the consequent derepression of CASZ1, a neuroblastoma tumour suppressor and a positive regulator of NGFR [40, 41]. The gene discussed is NGFR; the disease is neoplasm.