PRNP and neurodegenerative disease: The outstanding performance of prion RT-QuIC, and the discovery that other proteins involved in neurodegenerative diseases show a seeding-conversion behavior similar to that of PrP, prompted the scientific community to develop an RT-QuIC assay that could detect protein amyloids in more common neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s Disease (PD) in the CSF of diseased individuals.