Interestingly, 4 out of the 6 mitochondrial proteins that decreased in AD in both human and mouse CSFs were also reduced in the AD serum (i.e. ALDH6A1, ETFB, SOD2, and PRDX3), highlighting their robustness as the AD biofluid signature (Fig. 6b, Fig. S4). This evidence concerns the gene PRDX3 and Alzheimer disease.