To address this issue, we systematically integrated our ultra-deep CSF proteome with two other discovery-driven deep CSF proteomic studies in AD, resulting in 6 biomarker candidates that were repeatedly emerged in at least two independent studies including SMOC1, C1QTNF5, OLFML3, SPON1, SLIT2 and GPNMB. The gene discussed is SPON1; the disease is Alzheimer disease.