SIRT6 and diffuse large B-cell lymphoma: There was noted to be higher Sirt6 expression levels in DLBCL tissues compared to tissues with RHL upon IHC staining (Fig. 1c), with a Sirt6 positive rate of 80% (56 of 70) in DLBCL tissues compared to 8.6% (3 of 35) in tissues with RHL.