A maternal HF diet could aggravate the decrease of SIRT1 abundance induced by a postnatal HFHS diet [Hit 1: F (1,28) =0.92, P = 0.346; Hit 2: F (1,28) =11.41, P = 0.002; H1 and H2 interaction: F (1,28) =6.27, P = 0.018]. The gene discussed is SIRT1; the disease is hydrops fetalis.