We also evaluated the biological features, including the antioxidant capacity based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, inhibitory activities against human β-amyloid precursor cleavage enzyme (BACE1), human acetylcholinesterase (AChE), and antiproliferative activities toward five cancer cell lines (PC-3, MCF-7, A549, NCI-H727, and AGS), of bee pollen ethanol extracts (EBPs) for the first time. This evidence concerns the gene ACHE and cancer.