LEPR and obstructive sleep apnea syndrome: There was also a missense variant in LEPR (rs1137101) that had substantial evidence for a relationship with OSA in European Americans at Geisinger, including decreased risk for EHR-defined OSA (OR = 0.95, p = 3.78 × 10− 2) and associations with increased sleep efficiency (p = 2.28 × 10− 3), reduced wake after sleep onset (p = 2.64 × 10− 4), fewer awakenings (p = 9.40 × 10− 3) and shorter respiratory event duration (p = 3.01 × 10− 2).