In the tumor microenvironment, monocytes could potentially differentiate into tumor-associated macrophages (TAMs) promoting angiogenesis, extracellular matrix remodeling, tumor invasion, and metastasis by secreting epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), interleukin-6, interleukin-10, and metalloproteinase [49]. This evidence concerns the gene EGF and neoplasm.