When fully adjusted for age, gender, dialysis vintage, DM, Alb, cCa, P, iPTH, CRP and T-Cho, HD was also not significantly associated with faster progression of CAC than PD (adjusted difference: − 130.2 per year; 95% CI: − 308.0 to 47.5; P = 0.148) (Table 3). The gene discussed is CRP; the disease is diabetes mellitus.