There are several reports regarding the association between overexpression of DNA methyltransferases 1, 2 and 3 and DNA methylation in various cancers comprising gastric cancer (Ding et al., 2008), colon cancer HCT116, LS180, HT29/219, Caco2, and SW742 cell lines (Sarabi et al., 2015). Here, DNMT1 is linked to colonic neoplasm.