In the resent study, we evaluated the intrinsic growth potential using a Ki67 antibody (proliferation marker) (Brown and Gatter, 2002), tumor neoangiogenesis (CD105) (Dallas et al., 2008)and myofibroblast (α-SMA) expression (myofibroblast important role in invasion and metastasis) (Giatromanolaki et al., 2007) in OSCC and OSCC-OSF with respect to clinicopathological parameters. The gene discussed is MKI67; the disease is neoplasm.