In the light of these conflicting data we examined the genotypic frequency of XRCC1 gene and APE gene in a case-control study, The SNPs chosen for analysis were XRCC1 (Arg194Trp, Arg280His, Arg399Gln) and APE-1 Asp/148 Glu, The results indicated that the association with respect to His 280 genotype were significantly increased in relation to the relative risk of cervical cancer. The gene discussed is APEX1; the disease is cervical carcinoma.