Regarding EGF protein expression in HCC tissue, our present study showed that there was higher concentration of EGF in the tumor tissue (T) (200.00 ± 28.78) in patients with GG genotype compared to AG genotype (162.31 ± 30.86) and AA genotype (152.50 ± 35.00), p= 0.019. Here, EGF is linked to neoplasm.