CSF2 and acute myeloid leukemia: The human GM-CSF gene is ~ 2.5 kbp which is located in close proximity to the interleukin 3 gene within a T helper type 2-associated cytokine gene cluster at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and AML cases (Bowers et al., 2009).