However, other studies supported that NOTCH-1 mutations were associated with AML without morphological maturation (M0 or M1) (Takam Kamga et al., 2019; Noronha et al., 2019; Kannan et al., 2013; Sliwa et al., 2014; Lutherborrow et al., 2014). Here, NOTCH1 is linked to acute myeloid leukemia.