CASP3 and cancer: EAE of C. indica was applied against HeLa and CaSki, and it was found that this extract caused changes in cancer cells and nuclei, apoptosis and inhibited proliferation of these two cell lines and this mushroom extract increased the expression apoptotic genes (caspase 3, 9), tumor guard gene p53 and decreased the pro-apoptotic gene BcL2 (Ghosh et al., 2019).