However, several other studies (e.g. Liu et al. (Liu et al., 2012); Hou et al., (2014); Yang et al., (2016); Milevskiy et al., (2019) have examined and reported the significant roles of miR-196a in promoting proliferation, migration and invasion of NSCLC, cervical, epithelial ovarian and ER+ BC cell lines and malignant tissues in comparison with healthy tissues. Here, ESR1 is linked to breast cancer.