The allele frequencies of this polymorphism vary from 30% to 93% between different ethnic groups worldwide (Hodges et al., 2011) Several genetic epidemiological studies reported a positive association between this polymorphism in MDR1 gene and cancer risk such us, acute lymphoblastic leukemia, breast cancer, acute myeloid leukemia and non-hodgkin lymphoma (Talaat et al., 2018; Abuhaliema et al., 2016; Ait Boujmia et al., 2020; Kim et al., 2014). This evidence concerns the gene ABCB1 and acute myeloid leukemia.