SOX2 and neoplasm: Saffron extract at concentrations of 20, 40 and 100 μg/ml applied for 24, 48 and 72 hours reduced the expression self-renewal genes such as OCT4, KLF, SOX2, NANOG, and nucleostemin in gastric adenocarcinoma tumor cell line (Akbarpoor et al., 2020).