Several biologic factors, including tumor grade, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) have been integrated into the 8th AJCC pathological prognostic staging system, which provides a better predictive performance for prognosis compared to the 7th AJCC anatomic TNM stages [9–14]. Here, ERBB2 is linked to neoplasm.