Furthermore, multivariable Cox regression survival analysis shown that IGF2BP3 (HR = 4.27, 95%Confidence index (CI)1.637-11.1), HNRNPA2B1 (HR = 7.92, 95%CI 1.887-33.3), and METTL14 (HR = 3.38, 95%CI 1.039-11.0) were statistically meaningful risk factors of RFS in prostate cancer (Figure 4D). This evidence concerns the gene IGF2BP3 and Familial prostate cancer.