We presented IGF2BP3, HNRNPA2B1 and METTL14 were significantly related to RFS of prostate cancer based on mRNA expression information, while in the CNV-based regression model, YTHDF2, FTO, and ALKBH5 were notably associated with prognosis of prostate cancer. The gene discussed is YTHDF2; the disease is Familial prostate cancer.