We found that the copy number loss of ZC3H13, FTO, YTHDC2, WTAP and ALKBH5 decreased the protein expression in tumor samples, and meanwhile, patients with amplification of IGF2BP3, HNRNPA2B1 and IGF2BP2 presented higher expression level of these three proteins than normal tissues (Figure 6B, 6C). The gene discussed is ALKBH5; the disease is neoplasm.