In colorectal cancer cells prolidase overexpression was correlated with increased levels of nuclear hypoxia inducible factor 1α (HIF-1α) and HIF-1α-dependent gene products like a vascular endothelial growth factor (VEGF) and glucose transporter-1 (Glut-1)—important factors in cancer progression [105]. The gene discussed is HIF1A; the disease is colorectal cancer.