Experimentally validated databases (DIsplacement ANAlyzer [DIANA] tools, TarBase v.8 [21]), as well at databases with predicted interactions (TargetScan Release 7.2 [22]), predict a conserved 8-mer site of let-7e-5p within the 3′ untranslated region (UTR) of IRS2. Hepatic let-7e-5p was increased 1.2 ± 0.08-fold in individuals with type 2 diabetes (n = 29), as compared with non-diabetic obese participants (n = 49) (p = 0.0332; pa = 0.0450; Fig. 4a), and a negative correlation between let-7e-5p and IRS2 expression was found to exist (r = −0.4133, p = 1.7 × 10−4; q = 0.0019; Fig. 4b). The gene discussed is IRS2; the disease is type 2 diabetes mellitus.