Moreover, it has been demonstrated before that the Nrf2/HO-1 system is one of the most important endogenous defense mechanisms against hypoxic stress [61] and also in the acute intraocular hypertension glaucoma model it was observed that a novel marine neuroprotectant agent can protect RGCs from acute ischemia/reperfusion injury by enhancing the Nrf2/HO-1 pathway [62]. This evidence concerns the gene HMOX1 and glaucoma.