OSBPL3 is a differential expression gene that we screened using transcriptome gene expression chip (Affymetrix, HG-U133_Plus 2) in our earlier experiments, and the results show that OSBPL3 mRNA expression levels in colorectal cancer tissue and liver metastasis lesions are significantly higher than normal intestinal mucosa tissue (Supplementary Fig. S1A). The gene discussed is OSBPL3; the disease is medical procedure.