Systematic review37 confirms elevated proinflammatory cytokines in drug-naive FEP, including interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), IL-1β and sIL-2R, and there is clear evidence of elevated IL-6 in childhood, predicting risk for both psychosis and metabolic dysfunction. This evidence concerns the gene IL6 and psychotic disorder.